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M9490656.TXT
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1994-09-24
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Document 0656
DOCN M9490656
TI Conjugates of dendritic cells and memory T lymphocytes from skin
facilitate productive infection with HIV-1.
DT 9411
AU Pope M; Betjes MG; Romani N; Hirmand H; Cameron PU; Hoffman L; Gezelter
S; Schuler G; Steinman RM; Laboratory of Cellular Physiology and
Immunology Rockefeller; University, New York, New York 10021.
SO Cell. 1994 Aug 12;78(3):389-98. Unique Identifier : AIDSLINE
MED/94340730
AB Experimentally, a productive infection with HIV-1 requires that virus be
administered to T cells that are activated by mitogens. We describe a
productive milieu for HIV-1 within the confines of normal skin that does
not require standard stimuli. The milieu consists of dendritic cells and
T cells that emigrate from skin and produce distinctive stable,
nonproliferating conjugates. These conjugates, upon exposure to each of
seven different HIV-1 isolates, begin to release high levels of virus
progeny within 4 days. Numerous infected syncytia, comprised of both
dendritic and T cells, rapidly develop. We propose that conjugates of
dendritic cells and T cells, as found in the external linings of organs
involved in sexual transmission of HIV-1, represent an important site
for the productive phase of HIV-1 infection. Because the affected T
cells carry the memory phenotype, this site additionally provides a
mechanism for the chronic depletion of CD4+ memory cells in HIV-1
disease.
DE Cell Fusion Cell Movement Dendritic Cells/IMMUNOLOGY/*MICROBIOLOGY
Flow Cytometry Giant Cells/*MICROBIOLOGY Human HIV Core Protein
p24/ANALYSIS HIV Infections/ETIOLOGY/IMMUNOLOGY/TRANSMISSION
HIV-1/*GROWTH & DEVELOPMENT/IMMUNOLOGY Immunologic Memory
Skin/CYTOLOGY/IMMUNOLOGY/*MICROBIOLOGY Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. T4 Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).